These modifiers are cumulative. Two -1 modifiers means a V multiplier to the CV, and two V multipliers or a V and a -1 mean a 0 CV.
For example, a character with his hands bound in front and his feet bound apart is at V OCV, at V DCV and is at half running speed. A character with his hands bound in back and his feet bound together is at 0 OCV, 0 DCV and cannot run (though if he is able to get up, he can hop at 1" per Phase; the GM should require a DEX roll at -3 or an ordinary Acrobatics roll to stand up unassisted, and one DEX or Acrobatics roll per Phase of hopping).
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